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KMID : 1024220140290010024
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Environmental Health and Toxicology : EHT
2014 Volume.29 No. 1 p.24 ~ p.24
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Sub-acute toxicity study in female ICR mice following repetitive intramuscular injection of cervical cancer vaccines
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:Moon Seol-Hee
:Kim Du-Yeol/:Lee Jung-Min/:Park Hee-Won/:Lee Hye-Yeong/:Lee Yong-Hoon/:Lee Jae-Sung/:Jung Ji-won/:Kim Min-Ju/:Choi Kyoung-Baek/:Oh Yu-Kyoung/:Kim Young-Bong/:Kim Su-Jeong/:Oh Seung-Min
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Abstract
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Objectives: The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse- effect-level (NOAEL) of the cervical cancer vaccines was estimated.
Methods: Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×108, 5×108, and 2.5×109 copies/animal) of the cervical cancer vaccines.
Results: The cervical cancer vaccines did not show toxic responses for body weight, absolute/ relative organ weight, hematological/biochemical parameters, or histopathological parameters.
Conclusions: Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×109 copies/animal.
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KEYWORD
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Cervical cancer vaccine, Female ICR mice, Repetitive intramuscular injection
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